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About: DNA-(apurinic or apyrimidinic site) lyase     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatEnzymesOfKnownStructure, within Data Space : dbpedia.org associated with source document(s)

Type: ThingBiomoleculeBiomoleculeEnzymeyago:Abstraction100002137yago:Activator114723079yago:Catalyst114723628yago:Chemical114806838yago:Compound114818238yago:Enzyme114732946yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Protein114728724yago:Relation100031921enzymeproteinyago:Substance100019613yago:Thing100002452yago:Unit109465459yago:WikicatEnzymesOfKnownStructure New Facet based on Instances of this Class

The enzyme DNA-(apurinic or apyrimidinic site) lyase, also referred to as DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase (systematic name) or DNA AP lyase (EC 4.2.99.18) catalyzes the cleavage of the C-O-P bond 3' from the apurinic or apyrimidinic site in DNA via β-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. In the 1970s, this class of enzyme was found to repair at apurinic or apyrimidinic DNA sites in E. coli and in mammalian cells. The major active enzyme of this class in bacteria, and specifically, E. coli is endonuclease type III. This enzyme is part of a family of lyases that cleave carbon-oxygen bonds.