Cunningham Drug was a drugstore chain based in Detroit, Michigan. Founded in October 1889 by Andrew Cunningham, the chain operated primarily within the state of Michigan, and was once the largest drugstore chain in the state. Its Michigan locations were closed and reopened in 1982 as Apex Drug, and were later sold to Perry Drug Stores. The last stores remained open in Florida until 1991, when they were sold to Walgreens.