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About: Cord factor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : dbo:ChemicalCompound, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatVirulenceFactorsyago:Abstraction100002137yago:Beginning107290905yago:Cause107326557yago:Event100029378yago:Factor107327805yago:Happening107283608yago:Origin107323922yago:PsychologicalFeature100023100yago:YagoPermanentlyLocatedEntitychemical compound New Facet based on Instances of this Class

Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. The antimycobacterial drug SQ109 is thought to inhibit TDM production levels and in this way disrupts its cell wall assembly.