State Highway 389 (SH 389), in the U.S. state of Colorado is a state highway traversing through the Great Plains, and Black Mesa. SH 389's southern terminus is a continuation of New Mexico State Road 551 (NM 551) at the New Mexico state line. It continues north 1.5 miles to Branson. After leaving Branson the route travels through rural Las Animas county to its northern terminus at U.S. Route 160 (US 160).