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Cold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below 30 °C (86 °F), directed against red blood cells, causing them to agglutinate and undergo lysis. It is a form of autoimmune hemolytic anemia, specifically one in which antibodies bind red blood cells only at low body temperatures, typically 28–31 °C. Cold agglutinin disease was first described in 1957.

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  • داء الراصات الباردة
  • Cold agglutinin disease
  • Maladie des agglutinines froides
  • Sindrome cronica da agglutinine a frigore
  • Köldagglutininsjukdom
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  • داء الراصات الباردة هو مرض مناعة ذاتية يتصف بوجود تركيزاتٍ عالية من الأجسام المضادة الدوارة عادةً ما تكون كريين مناعي م (IgM) موجه ضد خلايا الدم الحمراء. وهو على وجه الخصوص شكلٌ من أشكال فقر الدم الانحلالي بالمناعة الذاتية، تربط فيه الأجسام المضادة خلايا الدم الحمراء فقط في درجات حرارة الجسم المنخفضة التي تتراوح غالبًا ما بين 28-31 درجة حرارة مئوية. وقد تم وصفه لأول مرة في عام 1957،
  • La maladie des agglutinines froides est une maladie auto-immune caractérisée par une forte concentration d'anticorps circulant, le plus souvent des IgM, dirigées contre les érythrocytes. C'est une forme d', plus précisément de celles où les anticorps lient uniquement les hématies entre elles à basse température, généralement entre 28 et 31 °C. Elle a été décrite pour la première fois en 1957.
  • La sindrome da agglutinine a frigore si manifesta come una malattia immunologia con caratteristiche presenze di autoanticorpi IgM che agglutinano in modo ottimale i globuli rossi a temperature molto basse, intorno ai 4 °C. Le crioagglutinine policlonali aumentano dopo che l'individuo viene assoggettato ad alcune infezioni, come micoplasmi, tripanosmiasi e malaria che raggiungono il loro limite in 2-3 settimane ma non sono significative se non mostrano segni emolitici.
  • Köldagglutininsjukdom är en autoimmun sjukdom som karaktäriseras av höga koncentrationer av cirkulerande antikroppar, vanligtvis av IgM-typ, som går på erytrocyterna (röda blodkroppar). Det finns två typer av köldagglutininsjukdom: * Primär köldagglutininsjukdom: okänt ursprung . * Sekundär köldagglutininsjukdom orsakat av: * Lymfoproliferativa sjukdomar hos vuxna, såsom lymfom och kronisk lymfatisk leukemi, eller infektion. * Infektion associerad med sjukdomar såsom HIV, mukoplasmapneumoni eller mononukleos.
  • Cold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below 30 °C (86 °F), directed against red blood cells, causing them to agglutinate and undergo lysis. It is a form of autoimmune hemolytic anemia, specifically one in which antibodies bind red blood cells only at low body temperatures, typically 28–31 °C. Cold agglutinin disease was first described in 1957.
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  • Cold agglutinin disease
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  • Cold agglutinin disease
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