Climbing fibers are the name given to a series of neuronal projections from the inferior olivary nucleus located in the medulla oblongata. These axons pass through the pons and enter the cerebellum via the inferior cerebellar peduncle where they form synapses with the deep cerebellar nuclei and Purkinje cells. Each climbing fiber will form synapses with 1-10 Purkinje cells. Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell.
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| - Climbing fiber (en)
- Fibra trepadora (es)
- Fibra rampicante (it)
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| - In anatomia la fibra rampicante è la ramificazione terminale di un assone olivo-cerebellare, che origina nel dell'oliva inferiore (situato nel midollo allungato) e si proietta alla corteccia del cervelletto, innervando le cellule di Purkinje. Nell'adulto e in condizioni non patologiche ciascuna fibra rampicante innerva una sola cellula di Purkinje e ciascuna cellula di Purkinje è innervata da una fibra rampicante. Insieme alle costituisce l'unica innervazione eccitatoria delle cellule di Purkinje. (it)
- Climbing fibers are the name given to a series of neuronal projections from the inferior olivary nucleus located in the medulla oblongata. These axons pass through the pons and enter the cerebellum via the inferior cerebellar peduncle where they form synapses with the deep cerebellar nuclei and Purkinje cells. Each climbing fiber will form synapses with 1-10 Purkinje cells. Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell. (en)
- La fibra trepadora es una serie de proyecciones neuronales proveniente de localizada en el bulbo raquídeo (medulla oblongata). Estos axones pasan a través del puente troncoencefálico (Pons (cerebro)) y entran al cerebelo vía los donde ellos forman sinapsis con el y las células de Purkinje. Cada fibra trepadora forma sinapsis con 1 a 10 células de Purkinje. Se ha demostrado que en este tipo de lesión inducida por brote, se necesita el factor de crecimiento asociado a la proteína . (es)
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| - Microcircuitry of the cerebellum. Excitatory synapses are denoted by and inhibitory synapses by . Climbing fiber is shown originating from the inferior olive . (en)
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| - Inferior olive and Cerebellum (en)
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| - Climbing fibers are the name given to a series of neuronal projections from the inferior olivary nucleus located in the medulla oblongata. These axons pass through the pons and enter the cerebellum via the inferior cerebellar peduncle where they form synapses with the deep cerebellar nuclei and Purkinje cells. Each climbing fiber will form synapses with 1-10 Purkinje cells. Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell. These fibers provide very powerful, excitatory input to the cerebellum which results in the generation of complex spike excitatory postsynaptic potential (EPSP) in Purkinje cells. In this way climbing fibers (CFs) perform a central role in motor behaviors. The climbing fibers carry information from various sources such as the spinal cord, vestibular system, red nucleus, superior colliculus, reticular formation and sensory and motor cortices.Climbing fiber activation is thought to serve as a motor error signal sent to the cerebellum, and is an important signal for . In addition to the control and coordination of movements, the climbing fiber afferent system contributes to sensory processing and cognitive tasks likely by encoding the timing of sensory input independently of attention or awareness. In the central nervous system, these fibers are able to undergo remarkable regenerative modifications in response to injuries, being able to generate new branches by sprouting to innervate surrounding Purkinje cells if these lose their CF innervation. This kind of injury-induced sprouting has been shown to need the growth associated protein GAP-43. (en)
- La fibra trepadora es una serie de proyecciones neuronales proveniente de localizada en el bulbo raquídeo (medulla oblongata). Estos axones pasan a través del puente troncoencefálico (Pons (cerebro)) y entran al cerebelo vía los donde ellos forman sinapsis con el y las células de Purkinje. Cada fibra trepadora forma sinapsis con 1 a 10 células de Purkinje. En el desarrollo temprano, las células de Purkinje son inervadas por múltiples fibras trepadoras, pero conforme el cerebelo madura, estas aferencias se van eliminando gradualmente, resultando en que una sola fibra trepadora inerva a cada célula de Purkinje. Estas fibras proporcionan una muy poderosa entrada excitatoria al cerebelo, que resulta en la generación de espigas complejas de potencial excitatorio postsinaptico (PEPS) en las células de Purkinje. De esta manera, las fibras trepadoras (CFs) realizan un papel central en las conductas motoras. Las fibras trepadoras llevan información de varias fuentes como la médula espinal, el sistema vestibular, , colículo superior, formación reticular, y cortezas sensorial y motora. Se piensa que la activación sirve como una señal motora de error mandada hacia el cerebelo, y es una señal importante para la coordinación motora. Además del control y coordinación del movimiento, el sistema aferente de las fibras trepadoras contribuye al procesamiento sensorial y cognitivo de tareas como la codificación temporal de las aferencias sensoriales independientemente del estado de vigilia o atención. En el sistema nervioso central, estas fibras son capaces de someterse a modificaciones notables de regeneración en respuesta a las lesiones, siendo capaces de generar nuevas ramas de germinación inervando células de Purkinje cercanas si éstas pierden su inervación CF. Se ha demostrado que en este tipo de lesión inducida por brote, se necesita el factor de crecimiento asociado a la proteína . (es)
- In anatomia la fibra rampicante è la ramificazione terminale di un assone olivo-cerebellare, che origina nel dell'oliva inferiore (situato nel midollo allungato) e si proietta alla corteccia del cervelletto, innervando le cellule di Purkinje. Nell'adulto e in condizioni non patologiche ciascuna fibra rampicante innerva una sola cellula di Purkinje e ciascuna cellula di Purkinje è innervata da una fibra rampicante. Insieme alle costituisce l'unica innervazione eccitatoria delle cellule di Purkinje. (it)
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| - Unique excitatory function (en)
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| - Unique projection neuron (en)
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