Sir Christopher Wren PRS FRS (/rɛn/; 30 October 1632 [O.S. 20 October] – 8 March 1723 [O.S. 25 February]) was one of the most highly acclaimed English architects in history, as well as an anatomist, astronomer, geometer, and mathematician-physicist. He was accorded responsibility for rebuilding 52 churches in the City of London after the Great Fire in 1666, including what is regarded as his masterpiece, St Paul's Cathedral, on Ludgate Hill, completed in 1710.