Charles William Grube (June 11, 1904 – January 21, 1976) was an American football player. Grube was born in 1904 in Saginaw, Michigan, attended Arthur Hill High School in that city. He then enrolled at the University of Michigan where he played college football at the end position for the Michigan Wolverines football team from 1923 to 1925. He played at fullback in 1923, but was moved to end in 1925. At the time, one sports writer noted: "Grube has all the essentials of a good end ... He is a sure and hard tackler can handle a ball and is perhaps a better on defense than he is on offense." He played on the 1925 Michigan Wolverines football team that included quarterback Benny Friedman and fellow end Bennie Oosterbaan.