The Cacapon River (locally /kəˈkeɪpən/ kə-KAY-pən; meaning Medicine Waters), located in the Appalachian Mountains of West Virginia's Eastern Panhandle region, is an 81.0-mile-long (130.4 km) shallow river known for its fishing, boating, wildlife, hunting, and wilderness scenery. As part of the Potomac River watershed, it is an American Heritage River.