The Buffalo and Susquehanna Railroad was a railroad company that formerly operated in western and north central Pennsylvania and western New York. It was created in 1893 by the merger and consolidation of several smaller logging railroads. It operated independently until 1929, when a majority of its capital stock was purchased by the Baltimore and Ohio Railroad. At the same time, the B&O also purchased control of the neighboring Buffalo, Rochester, and Pittsburgh Railway. The Baltimore and Ohio officially took over operations of both roads in 1932.