Bartholomew O'Keeffe (born 2 April 1945) is a former Irish Fianna Fáil politician who served as Minister for Enterprise, Trade and Innovation from 2010 to 2011, Minister for Education and Science from 2008 to 2010 and a Minister of State from 2004 to 2008. He served as a Teachta Dála (TD) from 1987 to 1989 and from 1992 to 2011. He was a Senator for the Labour Panel from 1989 to 1992.