About: BQ-123

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BQ-123, also known as cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu-), is a cyclic pentapeptide that was first isolated from a fermentation broth of Streptomyces misakiensis in 1991. NMR studies indicate that the polypeptide backbone consists of a type II beta turn and an inverse gamma turn. The side-chains adopt different orientations depending on the solvent used. The proline carbonyl oxygen atom located at the onset of a beta turn is a sodium ion binding site. It has a high affinity for sodium ions and can coordinate up to three of them. Studies have shown that BQ123 is effective in reversing Ischemia-induced acute renal failure, and it has been suggested that this might be because BQ123 increases reabsorption of sodium ions in the proximal tubule cells.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Chemical compound yago:Adversary109773245 yago:CausalAgent100007347 yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:YagoLegalActor yago:YagoLegalActorGeo chemical compound yago:Whole100003553 yago:WikicatEndothelinReceptorAntagonists umbel-rc:ChemicalSubstanceType
rdfs:label	BQ-123 (en)
rdfs:comment	BQ-123, also known as cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu-), is a cyclic pentapeptide that was first isolated from a fermentation broth of Streptomyces misakiensis in 1991. NMR studies indicate that the polypeptide backbone consists of a type II beta turn and an inverse gamma turn. The side-chains adopt different orientations depending on the solvent used. The proline carbonyl oxygen atom located at the onset of a beta turn is a sodium ion binding site. It has a high affinity for sodium ions and can coordinate up to three of them. Studies have shown that BQ123 is effective in reversing Ischemia-induced acute renal failure, and it has been suggested that this might be because BQ123 increases reabsorption of sodium ions in the proximal tubule cells. (en)
foaf:depiction
dcterms:subject	Endothelin receptor antagonists Heterocyclic compounds with 1 ring Cyclic peptides Pentapeptides
Wikipage page ID	25335781 (xsd:integer)
Wikipage revision ID	1096097359 (xsd:integer)
Link from a Wikipage to another Wikipage	Endothelin receptor antagonists Endothelin receptor Endothelin receptor antagonist Heterocyclic compounds with 1 ring Streptomyces misakiensis Cyclic peptides Pentapeptides
sameAs	BQ-123 BQ-123 BQ-123 BQ-123 BQ-123 BQ-123 BQ-123 BQ-123
dbp:wikiPageUsesTemplate	dbt:Biochem-stub dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Portal_bar dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:HPhrases dbt:PPhrases dbt:Stdinchicite
thumbnail	wiki-commons:Special:FilePath/BQ-123_structure.svg?width=300
ImageFile	BQ-123 structure.svg (en)
IUPACName	2 (xsd:integer)
OtherNames	Cyclo (en)
Verifiedfields	changed (en)
verifiedrevid	393276085 (xsd:integer)
Watchedfields	changed (en)
has abstract	BQ-123, also known as cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu-), is a cyclic pentapeptide that was first isolated from a fermentation broth of Streptomyces misakiensis in 1991. NMR studies indicate that the polypeptide backbone consists of a type II beta turn and an inverse gamma turn. The side-chains adopt different orientations depending on the solvent used. The proline carbonyl oxygen atom located at the onset of a beta turn is a sodium ion binding site. It has a high affinity for sodium ions and can coordinate up to three of them. Studies have shown that BQ123 is effective in reversing Ischemia-induced acute renal failure, and it has been suggested that this might be because BQ123 increases reabsorption of sodium ions in the proximal tubule cells. BQ-123 is a selective ETA endothelin receptor antagonist. As such, it is used as a biochemical tool in the study of endothelin receptor function. BQ-123 works as an ET-1 antagonist by reversing already established contractions to ET-1. This indicates that BQ-123 can work as an antagonist to remove ET-1 from its receptor (ETA). (en)
gold:hypernym	Peptide
prov:wasDerivedFrom	wikipedia-en:BQ-123?oldid=1096097359&ns=0
page length (characters) of wiki page	9425 (xsd:nonNegativeInteger)
alternative name	Cyclo((D)-trp-(D)-asp-(L)-pro-(D)-val-(L)-leu) (en)
IUPAC name	2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid (en)
foaf:isPrimaryTopicOf	wikipedia-en:BQ-123
is Link from a Wikipage to another Wikipage of	BQ BQ123 Endothelin receptor antagonist List of compounds with carbon numbers 30–39 C31H42N6O7 List of signaling peptide/protein receptor modulators Signaling peptide receptor Solute carrier organic anion transporter family member 1B3 BQ 123
is Wikipage redirect of	BQ123 C31H42N6O7 BQ 123
is Wikipage disambiguates of	BQ
is foaf:primaryTopic of	wikipedia-en:BQ-123

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