Andrew Setefano (born 10 August 1987) is a Samoan professional footballer who plays as a defender for Lupe o le Soaga. He has been a member of the Samoa national football team since 2011. Setefano is from Moamoa-fou, Satuimalufilufi and Vaito'omuli. He has played football for Upper Hutt City FC in New Zealand, Hekari United F.C. in Papua New Guinea, Goldstar Sogi FC, Vailima Kiwi FC, and Lupe o le Soaga in Samoa. He played for Vailima Kiwi FC in the 2019 OFC Champions League, and was suspended during the opening match. He captained Lupe o le Soaga in the 2020 OFC Champions League.