The 49th Annual American Music Awards were held on November 21, 2021, at the Microsoft Theater in Los Angeles, recognizing the most popular artists, singles and albums of 2021. Cardi B hosted the ceremony, following Queen Latifah (1995) as the only female rappers in history to do so. Cardi B became the first artist to win Favorite Rap/Hip Hop Song three times. BTS, Doja Cat, and Megan Thee Stallion won three awards each.