About: Alpha-thalassemia

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Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 and HBA2. Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin, the molecule that carries oxygen in the blood. Normal hemoglobin consists of two alpha chains and two beta chains; in alpha-thalassemia, there is a quantitative decrease in the amount of alpha chains, resulting in fewer normal hemoglobin molecules. Furthermore, alpha-thalassemia leads to the production of unstable beta globin molecules which cause increased red blood cell destruction. The degree of impairment is based on which clinical phenotype is present (how many genes are affected).

Attributes	Values
rdf:type	Thing Fuchs' dystrophy yago:WikicatAnemias yago:WikicatBloodDisorders yago:Abstraction100002137 yago:Anemia114195315 yago:Attribute100024264 yago:BloodDisease114189204 yago:BloodDyscrasia114053850 yago:Condition113920835 yago:Disease114070360 yago:Disorder114052403 yago:Dyscrasia114053717 yago:GeneticDisease114151139 yago:HemolyticAnemia114165240 yago:IllHealth114052046 yago:Illness114061805 yago:PathologicalState114051917 yago:PhysicalCondition114034177 yago:WikicatGeneticDisorders yago:WikicatHereditaryHemolyticAnemias disease yago:State100024720 yago:WikicatDisordersOfGlobinAndGlobulinProteins umbel-rc:AilmentCondition
rdfs:label	Alpha-thalassemia (en) ثلاسيميا ألفا (ar) Α-Thalassämie (de) Thalassémie alpha (fr) Alfa talassemia (it)
rdfs:comment	الالفا ثلاسيما (بالإنجليزية: Alpha-thalassemia)‏ هو أحد أنواع الثلاسيميا يتصف بنقص أو انعدام في تكوين السلسلة ألفا، أحد مكونات الهيموغلوبين الأساسية. وهذا النوع من الثلاسيما يتصف بقلة شيوعه. (ar) Alpha-Thalassämie (α-Thalassämie) ist eine Form der Thalassämie, welche die Gene HBA1 und HBA2 mit einbezieht. Alpha-Thalassämie ist auf eine verminderte Produktion von 1,2,3 oder 4 alpha-Globin-Ketten zurückzuführen, was zu einem relativen hohem Überschuss an beta-Globin-Ketten führt. Der Grad der Störung hängt davon ab, welcher klinische Phänotyp vorhanden ist bzw. wie viele Ketten betroffen sind. (de) Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 and HBA2. Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin, the molecule that carries oxygen in the blood. Normal hemoglobin consists of two alpha chains and two beta chains; in alpha-thalassemia, there is a quantitative decrease in the amount of alpha chains, resulting in fewer normal hemoglobin molecules. Furthermore, alpha-thalassemia leads to the production of unstable beta globin molecules which cause increased red blood cell destruction. The degree of impairment is based on which clinical phenotype is present (how many genes are affected). (en) La thalassémie alpha est une maladie génétique en rapport avec une anomalie de la synthèse de la chaîne alpha de l'hémoglobine, se traduisant par une anémie plus ou moins prononcée. Il s'agit de l'une des deux formes de thalassémies, l'autre étant la thalassémie bêta. (fr) L'alfa-talassemia (α-talassemia) è un tipo di talassemia che coinvolge i geni che codificano per le emoglobine HbA e HbA2.. La malattia è caratterizzata dalla compromissione della produzione di una, due, tre o addirittura tutte e quattro le catene α dell'emoglobina, che correla direttamente con la gravità clinica della malattia. (it)
foaf:name	Alpha-thalassemia (en)
name	Alpha-thalassemia (en)
foaf:depiction
dcterms:subject	Disorders of globin and globulin proteins Hereditary hemolytic anemias
Wikipage page ID	4210617 (xsd:integer)
Wikipage revision ID	1090845187 (xsd:integer)
Link from a Wikipage to another Wikipage	Beta-thalassaemia Blood transfusions Complete blood count Erythropoiesis Gene therapy Genetic disorder Genetic screen Serum iron Gallstone Gallstones Greek Cypriots Homozygote Anemia Malaria Sub-Saharan Africa Hemoglobin Barts Hemoglobin H disease Hemoglobin electrophoresis Hemoglobinopathy Microcytic anemia Brilliant cresyl blue Turkish Cypriots Heinz body Iron-deficiency anemia Alpha chain Disorders of globin and globulin proteins Hereditary hemolytic anemias Capillary electrophoresis Beta-thalassemia Chromosome 16 Delta-thalassemia Red blood cell Red blood cell indices HBB HGB Hemoglobin, alpha 1 Hepatosplenomegaly High-performance liquid chromatography Jaundice Thalassemia Hydrops fetalis Skull bossing Homologous chromosome Phenotype Southeast Asia Splenectomy Splenomegaly Fetus Near East New methylene blue Oedema Recessive Mediterranean Basin Extramedullary hematopoiesis Hypertensive disease of pregnancy Thrombosis

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