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Adenosylcobalamin (AdoCbl), also known as coenzyme B12, cobamamide, and dibencozide, is, along with methylcobalamin (MeCbl), one of the biologically active forms of vitamin B12. Adenosylcobalamin participates as a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These processes require the formation of the deoxyadenosyl radical through homolytic dissociation of the carbon-cobalt bond. This bond is exceptionally weak, with a bond dissociation energy of 31 kcal/mol, which is further lowered in the chemical environment of an enzyme active site. An enzyme that uses adenosylcobalamin as a cofactor is methylmalonyl-CoA mutase (MCM).

AttributesValues
rdf:type
rdfs:label
  • Adenosylcobalamin (en)
  • Cobamamida (es)
  • Adénosylcobalamine (fr)
  • Cobamamide (it)
  • コバマミド (ja)
  • 아데노실코발라민 (ko)
  • Adenosylcobalamine (nl)
  • Кобамамид (ru)
  • Cobamamida (pt)
rdfs:comment
  • L'adénosylcobalamine, également appelée cobamamide, adocobalamine, voire dibencozide, est l'une des formes actives de vitamine B12, avec la méthylcobalamine. Elle est disponible commercialement sous forme de comprimés, mais pas sous forme injectable, contrairement aux trois autres formes de vitamine B12 (méthylcobalamine, hydroxocobalamine et cyanocobalamine). La méthylmalonyl-CoA mutase est une enzyme qui utilise l'adénosylcobalamine comme cofacteur. (fr)
  • 아데노실코발라민(영어: adenosylcobalamin, AdoCbl)은 메틸코발라민(MeCbl)과 함께 생물학적으로 활성 형태의 비타민 B12 중 하나이다. 조효소 B12(영어: coenzyme B12), 코밤아마이드(영어: cobamamide), 다이벤코자이드(영어: dibencozide)이라고도 한다. 아데노실코발라민은 라디칼 매개 1,2-탄소 골격 자리옮김 반응에 보조 인자로 참여한다. 이러한 과정은 탄소-코발트 결합의 균질 해리를 통한 디옥시아데노실 라디칼의 형성을 필요로 한다. 이 결합은 31 kcal/mol의 결합 해리 에너지로 매우 약하며, 효소 활성 부위의 화학적 환경에서 더 낮아진다. 아데노실코발라민을 보조 인자로 사용하는 효소로는 (MCM)가 있다. (ko)
  • コバマミド （Cobamamide(AdoCbl)）は、アデノシルコバラミン（adenosylcobalamin）やジベンコザイド（dibencozide）とも呼ばれており、 メチルコバラミン（methylcobalamin(MeCbl)）とともに活性型のビタミンB12の一つである。 アデノシルコバラミンは、メチルマロニルCoAムターゼ (MCM) の補因子として利用されている。 (ja)
  • Cobamamide (AdoCbl), conosciuta anche con il nome di adenosilcobalamina o dibencozide è, insieme alla metilcobalamina (MeCbl), una delle forme attive della vitamina B12. È utilizzato sia in campo medico che veterinario, dove viene utilizzato come anabolizzante, nei ritardi della crescita o di insufficienti o stentati incrementi ponderali. Trova impiego anche come ricostitutivo nella convalescenza, iporessia ed anoressia. Usato anche come coadiuvante nelle epatopatie e neuropatie, come stimolante nella sindrome da fatica e con scarso rendimento negli animali atleti, come cavalli e cani. (it)
  • Кобаламид (англ. Adenosylcobalamin (AdoCbl)) — витамин, также известный как аденозилкобаламин и дибенкозид. Вместе с метилкобаламином (MeCbl) является одной из активных форм витамина B12. В качестве пищевой добавки доступен в форме таблеток, но (в отличие от цианкобаламина, метилкобаламина и гидроксокобаламина) его невозможно вводить в кровь напрямую. Отличается от цианокобаламина тем, что атом кобальта в последнем присоединен к цианогруппе. (ru)
  • Adenosylcobalamin (AdoCbl), also known as coenzyme B12, cobamamide, and dibencozide, is, along with methylcobalamin (MeCbl), one of the biologically active forms of vitamin B12. Adenosylcobalamin participates as a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These processes require the formation of the deoxyadenosyl radical through homolytic dissociation of the carbon-cobalt bond. This bond is exceptionally weak, with a bond dissociation energy of 31 kcal/mol, which is further lowered in the chemical environment of an enzyme active site. An enzyme that uses adenosylcobalamin as a cofactor is methylmalonyl-CoA mutase (MCM). (en)
  • La cobamamida es una coenzima de la vitamina B12, presente en varios tejidos animales y en tejidos humanos. También se conoce como adenosilcobalamina y dibencozida. Posee la propiedad de intervenir en los procesos metabólicos de síntesis proteica (metabolismo de las proteínas), especialmente los realizados en el hígado, siendo esencial para el crecimiento y el eutrofismo del parénquima hepático. Posee acción moderada contra la anemia y sobre el sistema nervioso central y periférico, como neurotrófico y neurorregenerador. (es)
  • A Cobamamida é uma coenzima da vitamina B12, presente em vários tecidos animais e no ser humano. É uma substância que possui a propriedade de intervir nos processos metabólicos da síntese protéica (metabolismo de proteínas), especialmente os realizados no fígado, sendo essencial para o crescimento e o eutrofismo do . É uma substância muito bem tolerada pelo organismo humano, sendo praticamente desprovido de efeitos colaterais. Atua nos distúrbios metabólicos do crescimento, sendo muitas vezes prescrita para pacientes pré-adolescentes com dificuldade em seu desenvolvimento. (pt)
  • Adenosylcobalamine, ook wel co-enzym B12 of cobamamide (AdoCbl), is een van de biologisch actieve vormen van vitamine B12. Samen met de andere cobalamines is het een complexe organische verbinding die van groot belang is voor diverse stofwisselingsprocessen. Adenosylcobalamine is in veel landen in tabletvorm verkrijgbaar. Een belangrijk enzym dat adenosylcobalamine als cofactor gebruikt, is methylmalonyl-CoA-mutase (MCM), dat in de mitochondria verantwoordelijk is voor de oxidatie van aminozuren met een vertakte keten. (nl)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/AdoCbl-ColorCoded.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Cobamamide_3D_sticks.png
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ATC suffix
  • BA04 (en)
ATC prefix
  • B03 (en)
c
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image
  • Cobamamide 3D sticks.png (en)
IUPAC name
  • Coα-[α-]-Coβ- (en)
  • cobamide (en)
KEGG
  • D00042 (en)
legal US
  • OTC (en)
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PubChem
routes of administration
  • Oral (en)
StdInChI
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