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Acute fatty liver of pregnancy is a rare life-threatening complication of pregnancy that occurs in the third trimester or the immediate period after delivery. It is thought to be caused by a disordered metabolism of fatty acids by mitochondria in the mother, caused by long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. The condition was previously thought to be universally fatal, but aggressive treatment by stabilizing the mother with intravenous fluids and blood products in anticipation of early delivery has improved prognosis.

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  • Acute fatty liver of pregnancy
  • Ostre stłuszczenie wątroby ciężarnych
  • Fígado gorduroso da gravidez
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  • Acute fatty liver of pregnancy is a rare life-threatening complication of pregnancy that occurs in the third trimester or the immediate period after delivery. It is thought to be caused by a disordered metabolism of fatty acids by mitochondria in the mother, caused by long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. The condition was previously thought to be universally fatal, but aggressive treatment by stabilizing the mother with intravenous fluids and blood products in anticipation of early delivery has improved prognosis.
  • Ostre stłuszczenie wątroby ciężarnych – rzadkie, zagrażające życiu powikłanie ciąży, które występuje w trzecim trymestrze ciąży lub bezpośrednio po porodzie. Uważa się, że jest powodowane zaburzonym metabolizmem kwasów tłuszczowych w mitochondriach matki, spowodowanym niedoborem enzymu LCHAD (dehydrogenaza 3-hydroksyacyl-koenzymu A długołańcuchowych kwasów tłuszczowych). Wcześniej uważano, że ostre stłuszczenie wątroby ciężarnych wiąże się z dużą umieralnością, ale intensywne leczenie stabilizujące stan matki poprzez dożylne podawanie płynów i produktów krwiopochodnych, z oczekiwaniem na możliwość wczesnego zakończenia ciąży, poprawiło rokowanie.
  • Fígado gorduroso da gravidez ou Esteatose hepática gestacional é uma complicação grave da gravidez que ocorre no terceiro trimestre de gestação ou no pós-parto imediato. Fígado gorduroso da gravidez afeta cerca de uma em cada 10.000 grávidas. A mortalidade foi significativamente reduzida para 18% e atualmente está relacionada, principalmente, às complicações, particularmente CID (Coagulação Intravascular Disseminada) e infecções. É mais comum na primeira gravidez e na gestação de gêmeos.
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  • Acute fatty liver of pregnancy
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  • Acute fatty liver of pregnancy
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