Acme is an unincorporated community in Donegal Township, Westmoreland County, Pennsylvania, Mount Pleasant Township, Westmoreland County, Pennsylvania, and Bullskin Township, Fayette County, Pennsylvania in the United States. The Acme ZIP code of 15610 extends well beyond the more densely populated part of the area, into rural parts of Donegal Township in Westmoreland County and Bullskin Township in Fayette County.