About: Acetylmethadol

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Acetylmethadol, also known as methadyl acetate, is a synthetic opioid analgesic. It is a racemic mixture of alphacetylmethadol (α-acetylmethadol) and betacetylmethadol (β-acetylmethadol), which are in turn racemic mixtures of levacetylmethadol (LAAM; L-α-acetylmethadol) and D-α-acetylmethadol and L-β-acetylmethadol and D-β-acetylmethadol, respectively. Hence, acetylmethadol has four possible optical isomers. All of these isomers have been shown to partially or fully substitute for the discriminative stimulus effects of heroin in rats, and thus it can be inferred that, in addition to LAAM which is used clinically as such, they are all likely to be active opioid analgesics in humans.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Pill (pharmacy) yago:WikicatAmines yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Amine114739004 yago:Chemical114806838 yago:Compound114818238 yago:Ester114850483 yago:Material114580897 yago:Matter100020827 yago:MethaneSeries114951377 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 drug yago:Substance100019613 yago:WikicatAcetateEsters
rdfs:label	Acetylmethadol (de) Acetylmethadol (en) Acetilmetadol (es) Acetylometadol (pl)
rdfs:comment	Acetylmethadol (INN) (auch: Methadyl acetate (USAN)) ist ein synthetisches Opioid-Analgetikum. Acetylmethadol ist nicht zu verwechseln mit Alphacetylmethadol (α-Acetylmethadol) oder Levacetylmethadol (L-α-Acetylmethadol). Acetylmethadol ist eine racemische Mischung aus Alphacetylmethadol und Betacetylmethadol, die wiederum Racemate aus Levacetylmethadol (LAAM; L-α-Acetylmethadol) und D-α-Acetylmethadol beziehungsweise L-β-Acetylmethadol und D-β-Acetylmethadol sind. Daher hat Acetylmethadol jeweils vier mögliche optische Isomere. Für alle diese Isomere konnte gezeigt werden, dass sie in der Lage sind, die Wirkungen von Heroin in Ratten teilweise oder vollständig zu ersetzen. (de) El acetilmetadol (Acetato de Metadil) es un analgésico narcótico de larga duración de la acción. Se utiliza principalmente en el tratamiento de la dependencia de narcóticos. (es) Acetylometadol – organiczny związek chemiczny, syntetyczny opioid. Znajduje się w grupie I-N Ustawy o przeciwdziałaniu narkomanii. Jest objęty Jednolitą konwencją o środkach odurzających z 1961 roku (wykaz I). (pl) Acetylmethadol, also known as methadyl acetate, is a synthetic opioid analgesic. It is a racemic mixture of alphacetylmethadol (α-acetylmethadol) and betacetylmethadol (β-acetylmethadol), which are in turn racemic mixtures of levacetylmethadol (LAAM; L-α-acetylmethadol) and D-α-acetylmethadol and L-β-acetylmethadol and D-β-acetylmethadol, respectively. Hence, acetylmethadol has four possible optical isomers. All of these isomers have been shown to partially or fully substitute for the discriminative stimulus effects of heroin in rats, and thus it can be inferred that, in addition to LAAM which is used clinically as such, they are all likely to be active opioid analgesics in humans. (en)
foaf:depiction
dcterms:subject	Acetate esters Analgesics Dimethylamino compounds Mu-opioid receptor agonists Synthetic opioids
Wikipage page ID	14743711 (xsd:integer)
Wikipage revision ID	1082618822 (xsd:integer)
Link from a Wikipage to another Wikipage	Betacetylmethadol United States Racemic mixture Acetate esters Analgesics Dimethylamino compounds Mu-opioid receptor agonists Controlled Substances Act Chemical synthesis Optical isomer Levacetylmethadol Analgesic Alphacetylmethadol List of Schedule I drugs (US) Synthetic opioids Heroin Biological activity Opioid Discriminative stimulus
sameAs	Acetylmethadol Acetylmethadol Acetylmethadol Acetylmethadol Acetylmethadol Acetylmethadol Acetylmethadol Acetylmethadol Acetylmethadol Acetylmethadol
USAN	methadyl acetate (en)
dbp:wikiPageUsesTemplate	dbt:Analgesic-stub dbt:Analgesics dbt:Drugbox dbt:Hatnote dbt:Opioidergics dbt:Reflist dbt:Short_description dbt:Cascite dbt:Fdacite dbt:Cholinergics
thumbnail	wiki-commons:Special:FilePath/Acetylmethadol.svg?width=300
ATC prefix	None (en)
c	23 (xsd:integer)
CAS number	509 (xsd:integer)
ChemSpiderID	10080 (xsd:integer)
DrugBank	DB01433 (en)
H	31 (xsd:integer)
IUPAC name	-6 (xsd:integer)
legal DE	Anlage I (en)
legal US	Schedule I (en)
n	1 (xsd:integer)
O	2 (xsd:integer)
PubChem	10517 (xsd:integer)
SMILES	O=CC (en)
StdInChI	1 (xsd:integer)
StdInChIKey	XBMIVRRWGCYBTQ-UHFFFAOYSA-N (en)
UNII	L59OC40KWJ (en)
has abstract	Acetylmethadol (INN) (auch: Methadyl acetate (USAN)) ist ein synthetisches Opioid-Analgetikum. Acetylmethadol ist nicht zu verwechseln mit Alphacetylmethadol (α-Acetylmethadol) oder Levacetylmethadol (L-α-Acetylmethadol). Acetylmethadol ist eine racemische Mischung aus Alphacetylmethadol und Betacetylmethadol, die wiederum Racemate aus Levacetylmethadol (LAAM; L-α-Acetylmethadol) und D-α-Acetylmethadol beziehungsweise L-β-Acetylmethadol und D-β-Acetylmethadol sind. Daher hat Acetylmethadol jeweils vier mögliche optische Isomere. Für alle diese Isomere konnte gezeigt werden, dass sie in der Lage sind, die Wirkungen von Heroin in Ratten teilweise oder vollständig zu ersetzen. (de) Acetylmethadol, also known as methadyl acetate, is a synthetic opioid analgesic. It is a racemic mixture of alphacetylmethadol (α-acetylmethadol) and betacetylmethadol (β-acetylmethadol), which are in turn racemic mixtures of levacetylmethadol (LAAM; L-α-acetylmethadol) and D-α-acetylmethadol and L-β-acetylmethadol and D-β-acetylmethadol, respectively. Hence, acetylmethadol has four possible optical isomers. All of these isomers have been shown to partially or fully substitute for the discriminative stimulus effects of heroin in rats, and thus it can be inferred that, in addition to LAAM which is used clinically as such, they are all likely to be active opioid analgesics in humans. In the United States, acetylmethadol and its individual isomers are all Schedule I drugs under the Controlled Substances Act, except LAAM, which is Schedule II and was used clinically until 2003. Acetylmethadol has an ACSCN of 9601. The isomers have individual ACSCNs, which are as follows: Alphacetylmethadol 9603, Betacetylmethadol 9607, LAAM 9648. All of the above have annual manufacturing quotas of 2 grams as of 2013, except LAAM, which is 4 grams. (en) El acetilmetadol (Acetato de Metadil) es un analgésico narcótico de larga duración de la acción. Se utiliza principalmente en el tratamiento de la dependencia de narcóticos. (es) Acetylometadol – organiczny związek chemiczny, syntetyczny opioid. Znajduje się w grupie I-N Ustawy o przeciwdziałaniu narkomanii. Jest objęty Jednolitą konwencją o środkach odurzających z 1961 roku (wykaz I). (pl)
legal AU	S8 (en)
legal CA	Schedule I (en)

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