The 2021 Blood and Guts was the inaugural Blood and Guts professional wrestling television special produced by All Elite Wrestling (AEW). The event aired on May 5, 2021, and took place at Daily's Place in Jacksonville, Florida. It was broadcast on TNT as a special episode of AEW's weekly television program, Dynamite. The event was previously scheduled to be held in March 2020 at the Prudential Center in Newark, New Jersey, but it was postponed for over a year due to the COVID-19 pandemic.