ADAMTS-4 endopeptidase (EC 3.4.24.82, aggrecanase-1) is an enzyme. This enzyme catalyses the following chemical reaction Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan This enzyme belongs to the peptidase family M12.