About: AB-001

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AB-001 (1-pentyl-3-(1-adamantoyl)indole) is a designer drug that was found as an ingredient in synthetic cannabis smoking blends in Ireland in 2010 and Hungary and Germany in 2011. It is unclear who AB-001 was originally developed by, but it is structurally related to compounds such as AM-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are known to be potent cannabinoid agonists with moderate to high selectivity for CB2 over CB1. The first published synthesis and pharmacological evaluation of AB-001 revealed that it acts as a full agonist at CB1 (EC50 = 35 nM) and CB2 receptors (EC50 = 48 nM). However, AB-001 was found to possess only weak cannabimimetic effects in rats at doses up to 30 mg/kg, making it less potent than the carboxamide analogue APICA, which posse

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Pill (pharmacy) yago:Agent114778436 yago:CausalAgent100007347 yago:DesignerDrug103179489 yago:Drug103247620 yago:Matter100020827 yago:PhysicalEntity100001930 yago:PsychoactiveDrug104017137 drug yago:Substance100020090 yago:WikicatDesignerDrugs
rdfs:label	AB-001 (en)
rdfs:comment	AB-001 (1-pentyl-3-(1-adamantoyl)indole) is a designer drug that was found as an ingredient in synthetic cannabis smoking blends in Ireland in 2010 and Hungary and Germany in 2011. It is unclear who AB-001 was originally developed by, but it is structurally related to compounds such as AM-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are known to be potent cannabinoid agonists with moderate to high selectivity for CB2 over CB1. The first published synthesis and pharmacological evaluation of AB-001 revealed that it acts as a full agonist at CB1 (EC50 = 35 nM) and CB2 receptors (EC50 = 48 nM). However, AB-001 was found to possess only weak cannabimimetic effects in rats at doses up to 30 mg/kg, making it less potent than the carboxamide analogue APICA, which posse (en)
foaf:depiction
dcterms:subject	Cannabinoids Designer drugs Adamantanoylindoles
Wikipage page ID	33362332 (xsd:integer)
Wikipage revision ID	1082421097 (xsd:integer)
Link from a Wikipage to another Wikipage	List of designer drugs Cannabinoids Designer drugs Synthetic cannabis MN-25 UR-144 A-834,735 AB-005 AM-1248 APICA (synthetic cannabinoid drug) Adamantane JWH-018 JWH-250 Adamantanoylindoles RCS-4 RCS-8 Cannabinoid receptor 1 Cannabinoid receptor 2 Structural scheduling of synthetic cannabinoids
sameAs	AB-001 AB-001 AB-001 AB-001 AB-001 AB-001
dbp:wikiPageUsesTemplate	dbt:Cannabinoids dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Stdinchicite
thumbnail	wiki-commons:Special:FilePath/AB-001_structure.png?width=300
c	24 (xsd:integer)
CAS number	1345973 (xsd:integer)
ChemSpiderID	26286891 (xsd:integer)
H	31 (xsd:integer)
IUPAC name	1 (xsd:integer)
legal DE	Anlage II (en)
legal UK	Class B (en)
n	1 (xsd:integer)
O	1 (xsd:integer)
PubChem	57404070 (xsd:integer)
SMILES	CCCCCn1ccCC34CC5CCCCC4 (en)
StdInChI	1 (xsd:integer)
StdInChIKey	SHWDYCMMUPPWQM-UHFFFAOYSA-N (en)
UNII	H657DIA015 (en)
Verifiedfields	changed (en)
verifiedrevid	460440720 (xsd:integer)
Watchedfields	changed (en)
width	200 (xsd:integer)
has abstract	AB-001 (1-pentyl-3-(1-adamantoyl)indole) is a designer drug that was found as an ingredient in synthetic cannabis smoking blends in Ireland in 2010 and Hungary and Germany in 2011. It is unclear who AB-001 was originally developed by, but it is structurally related to compounds such as AM-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are known to be potent cannabinoid agonists with moderate to high selectivity for CB2 over CB1. The first published synthesis and pharmacological evaluation of AB-001 revealed that it acts as a full agonist at CB1 (EC50 = 35 nM) and CB2 receptors (EC50 = 48 nM). However, AB-001 was found to possess only weak cannabimimetic effects in rats at doses up to 30 mg/kg, making it less potent than the carboxamide analogue APICA, which possesses potent cannabimimetic activity at doses of 3 mg/kg. (en)
legal CA	Schedule II (en)
gold:hypernym	Pill (pharmacy)
prov:wasDerivedFrom	wikipedia-en:AB-001?oldid=1082421097&ns=0
page length (characters) of wiki page	5184 (xsd:nonNegativeInteger)
CAS number	1345973-49-0
FDA UNII code	H657DIA015
PubChem	57404070
foaf:isPrimaryTopicOf	wikipedia-en:AB-001
is Link from a Wikipage to another Wikipage of	List of designer drugs List of designer drugs Liebermann reagent List of miscellaneous designer cannabinoids List of psychedelic drugs STS-135 (drug) MAM-2201 MN-25 UR-144 Drugs controlled by the German Betäubungsmittelgesetz 4-HTMPIPO A-834,735 AB-005 AM-1248 Adamantane C24H31NO

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