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In enzymology, a 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase (EC 1.14.13.95) is an enzyme that catalyzes the chemical reaction 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O The 4 substrates of this enzyme are 7alpha-hydroxycholest-4-en-3-one (7 alpha-hydroxy-4-cholesten-3-one, NADPH, H+, and O2, whereas its 3 products are , NADP+, and H2O. This enzymatic activity is performed by CYP8B1.

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  • 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
  • 7α-ヒドロキシコレスト-4-エン-3-オン-12α-ヒドロキシラーゼ
  • 7alfa-idrossicolest-4-en-3-one 12alfa-idrossilasi
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  • La 7alfa-idrossicolest-4-en-3-one 12alfa-idrossilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 7α-idrossicolest-4-en-3-one + NADPH + H+ + O2 ⇄ 7α,12α-diidrossicolest-4-en-3-one + NADP+ + H2O L'enzima è una proteina eme- (P-450). Richiede la NADPH-emoproteina reduttasi (numero EC 1.6.2.4) ed il citocromo b5 per l'attività massima. Questo enzima è importante nella biosintesi dell'acido biliare, poiché è responsabile del bilanciamento tra la formazione dell'acido colico e quello chenodeossicolico.
  • 7α-ヒドロキシコレスト-4-エン-3-オン-12α-ヒドロキシラーゼ(7α-hydroxycholest-4-en-3-one 12α-hydroxylase)は、次の化学反応を触媒する酸化還元酵素である。 7α-ヒドロキシコレスト-4-エン-3-オン + NADPH + H+ + O2 7α,12α-ジヒドロキシコレスト-4-エン-3-オン + NADP+ + H2O この酵素の基質は、NADPH、H+とO2で、生成物は、NADP+とH2Oである。 組織名は7α-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12α-hydroxylating)で、別名に7α-hydroxy-4-cholesten-3-one 12α-monooxygenase、CYP12、sterol 12α-hydroxylase (ambiguous)、HCO 12α-hydroxylaseがある。
  • In enzymology, a 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase (EC 1.14.13.95) is an enzyme that catalyzes the chemical reaction 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O The 4 substrates of this enzyme are 7alpha-hydroxycholest-4-en-3-one (7 alpha-hydroxy-4-cholesten-3-one, NADPH, H+, and O2, whereas its 3 products are , NADP+, and H2O. This enzymatic activity is performed by CYP8B1.
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  • 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
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  • La 7alfa-idrossicolest-4-en-3-one 12alfa-idrossilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 7α-idrossicolest-4-en-3-one + NADPH + H+ + O2 ⇄ 7α,12α-diidrossicolest-4-en-3-one + NADP+ + H2O L'enzima è una proteina eme- (P-450). Richiede la NADPH-emoproteina reduttasi (numero EC 1.6.2.4) ed il citocromo b5 per l'attività massima. Questo enzima è importante nella biosintesi dell'acido biliare, poiché è responsabile del bilanciamento tra la formazione dell'acido colico e quello chenodeossicolico.
  • In enzymology, a 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase (EC 1.14.13.95) is an enzyme that catalyzes the chemical reaction 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O The 4 substrates of this enzyme are 7alpha-hydroxycholest-4-en-3-one (7 alpha-hydroxy-4-cholesten-3-one, NADPH, H+, and O2, whereas its 3 products are , NADP+, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating). This enzymatic activity is performed by CYP8B1. Other names used include 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase, CYP12, sterol 12alpha-hydroxylase (ambiguous), and HCO 12alpha-hydroxylase. This enzyme participates in .
  • 7α-ヒドロキシコレスト-4-エン-3-オン-12α-ヒドロキシラーゼ(7α-hydroxycholest-4-en-3-one 12α-hydroxylase)は、次の化学反応を触媒する酸化還元酵素である。 7α-ヒドロキシコレスト-4-エン-3-オン + NADPH + H+ + O2 7α,12α-ジヒドロキシコレスト-4-エン-3-オン + NADP+ + H2O この酵素の基質は、NADPH、H+とO2で、生成物は、NADP+とH2Oである。 組織名は7α-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12α-hydroxylating)で、別名に7α-hydroxy-4-cholesten-3-one 12α-monooxygenase、CYP12、sterol 12α-hydroxylase (ambiguous)、HCO 12α-hydroxylaseがある。
EC number
  • 1.14.13.95
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