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6-Phosphogluconolactonase (6PGL, PGLS) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose phosphate pathway. The tertiary structure of 6PGL employs an α/β hydrolase fold, with active site residues clustered on the loops of the α-helices. Based on the crystal structure of the enzyme, the mechanism is proposed to be dependent on proton transfer by a histidine residue in the active site. 6PGL selectively catalyzes the hydrolysis of δ-6-phosphogluconolactone, and has no activity on the γ isomer.

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  • 6-Phosphogluconolactonase
  • 6-phosphogluconolactonase
  • 6-Phosphogluconolactonase
  • 6-ホスホグルコノラクトナーゼ
  • 6-磷酸葡萄糖酸内酯酶
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  • 6-Phosphogluconolactonase (6PGL) (Gen: PGLS) ist das Enzym, das 6-Phosphogluconolacton zu 6-Phosphogluconat hydrolysiert. Diese Reaktion ist der zweite Teilschritt im Pentosephosphatweg. 6PGL kommt in den meisten Lebewesen vor. Die Expression der 6PGL ist erhöht in Brustkrebszellen, wie eine Proteomics-Studie zeigen konnte.
  • La 6-phosphogluconolactonase est une hydrolase de la voie des pentoses phosphates qui catalyse la réaction : Chez l'homme, elle est codée par le gène PGLS, situé sur le chromosome 19. 6-Phospho-gluconolactonase * Portail de la biochimie
  • 6-Phosphogluconolactonase (6PGL, PGLS) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose phosphate pathway. The tertiary structure of 6PGL employs an α/β hydrolase fold, with active site residues clustered on the loops of the α-helices. Based on the crystal structure of the enzyme, the mechanism is proposed to be dependent on proton transfer by a histidine residue in the active site. 6PGL selectively catalyzes the hydrolysis of δ-6-phosphogluconolactone, and has no activity on the γ isomer.
  • 6-ホスホグルコノラクトナーゼ(6-phosphogluconolactonase、EC 3.1.1.31)は、ペントースリン酸経路に関係する酵素である。6-ホスホグルコノ-1,5-ラクトンを6-ホスホグルコン酸に変換する。 * 6-ホスホグルコノ-1,5-ラクトン * 6-ホスホグルコン酸
  • 6-磷酸葡萄糖酸内酯酶(英語:6-Phosphogluconolactonase)是戊糖磷酸途径过程中的一个酶。它将6-磷酸葡糖酸内酯转变为6-磷酸葡萄糖酸。 * 6-磷酸葡糖酸内酯 * 6-磷酸葡萄糖酸
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  • 6-phosphogluconolactonase
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