In enzymology, a 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase (EC 1.14.13.96) is an enzyme that catalyzes the chemical reaction 5beta-cholestane-3alpha,7alpha-diol + NADPH + H+ + O2 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ + H2O The 4 substrates of this enzyme are , NADPH, H+, and O2, whereas its 3 products are , NADP+, and H2O.
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| - 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase (en)
- 5beta-colestano-3alfa,7alfa-diolo 12alfa-idrossilasi (it)
- 5β-コレスタン-3α,7α-ジオール-12α-ヒドロキシラーゼ (ja)
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| - In enzymology, a 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase (EC 1.14.13.96) is an enzyme that catalyzes the chemical reaction 5beta-cholestane-3alpha,7alpha-diol + NADPH + H+ + O2 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ + H2O The 4 substrates of this enzyme are , NADPH, H+, and O2, whereas its 3 products are , NADP+, and H2O. (en)
- 5β-コレスタン-3α,7α-ジオール-12α-ヒドロキシラーゼ（5β-cholestane-3α,7α-diol 12α-hydroxylase）は、次の化学反応を触媒する酸化還元酵素である。 5β-コレスタン-3α,7α-ジオール + NADPH + H+ + O2 5β-コレスタン-3α,7α,12α-トリオール + NADP+ + H2O この酵素の基質は、NADPH、H+とO2で、生成物は、NADP+とH2Oである。 組織名は5β-cholestane-3α,7α-diol,NADPH:oxygen oxidoreductase (12α-hydroxylating)で、別名に5β-cholestane-3α,7α-diol 12α-monooxygenase、sterol 12α-hydroxylase (ambiguous)、CYP8B1、cytochrome P450 8B1がある。 (ja)
- La 5beta-colestano-3alfa,7alfa-diolo 12alfa-idrossilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 5β-colestano-3α,7α-diolo + NADPH + H+ + O2 ⇄ 5β-colestano-3α,7α,12α-triolo + NADP+ + H2O (it)
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| - 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase (en)
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| - In enzymology, a 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase (EC 1.14.13.96) is an enzyme that catalyzes the chemical reaction 5beta-cholestane-3alpha,7alpha-diol + NADPH + H+ + O2 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ + H2O The 4 substrates of this enzyme are , NADPH, H+, and O2, whereas its 3 products are , NADP+, and H2O. (en)
- 5β-コレスタン-3α,7α-ジオール-12α-ヒドロキシラーゼ（5β-cholestane-3α,7α-diol 12α-hydroxylase）は、次の化学反応を触媒する酸化還元酵素である。 5β-コレスタン-3α,7α-ジオール + NADPH + H+ + O2 5β-コレスタン-3α,7α,12α-トリオール + NADP+ + H2O この酵素の基質は、NADPH、H+とO2で、生成物は、NADP+とH2Oである。 組織名は5β-cholestane-3α,7α-diol,NADPH:oxygen oxidoreductase (12α-hydroxylating)で、別名に5β-cholestane-3α,7α-diol 12α-monooxygenase、sterol 12α-hydroxylase (ambiguous)、CYP8B1、cytochrome P450 8B1がある。 (ja)
- La 5beta-colestano-3alfa,7alfa-diolo 12alfa-idrossilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 5β-colestano-3α,7α-diolo + NADPH + H+ + O2 ⇄ 5β-colestano-3α,7α,12α-triolo + NADP+ + H2O L'enzima è una proteina eme-tiolata (P-450). Questo è l'enzima chiave per la biosintesi dell'acido biliare, acido colico (acido 3α,7α,12α-triidrossi-5β-colanoico). L'attività di questo enzima determina la resa biosintetica dell'acido colico rispetto a quello chenodeossicolico. L'enzima è in grado anche di idrossilare il substrato nelle posizioni 25 e 26, ma con risultato peggiore. (it)
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