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About: 4-NEMD     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatMolecularFormulasyago:WikicatNaphthalenesyago:Abstraction100002137yago:Base114618253yago:Chemical114806838yago:Communication100033020yago:Compound114818238yago:Formula106816935yago:Hydrocarbon114911057yago:Imidazole114916670yago:Material114580897yago:Matter100020827yago:Message106598915yago:MolecularFormula106817173yago:Naphthalene114958564yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Relation100031921yago:WikicatImidazolesdrugyago:Statement106722453yago:Substance100019613umbel-rc:DrugProduct New Facet based on Instances of this Class

4-NEMD is a potent sedative drug which acts as a selective alpha-2 adrenergic agonist. It is closely related to dexmedetomidine but is several times more potent. Like other alpha-2 agonists, it produces sedative and muscle relaxant effects but without producing respiratory depression. It is not currently used in medicine but has been researched as the basis for a potential new generation of alpha-2 agonist drugs, which may have selectivity for the different subtypes of the alpha-2 receptor. It has two isomers, with the (S) isomer being the more potent, as with medetomidine. 4-NEMD was also investigated by the United States military as an anaesthetic agent, most likely for use in surgery but possibly also for use as a non-lethal incapacitating agent, although this has not been officially co