The 2nd Missouri Infantry Regiment was an infantry regiment that served in the Confederate States Army during the American Civil War. Organized on January 16, 1862, the regiment first saw major action at the Battle of Pea Ridge on March 7 and 8, 1862. After Pea Ridge, the regiment was transferred across the Mississippi River, fighting in the Battle of Farmington, Mississippi on May 9. The unit missed the Battle of Iuka in September, but was heavily engaged at the Second Battle of Corinth on October 3 and 4. The regiment helped drive in a Union position on October 3. On October 4, the 2nd Missouri Infantry, along with the rest of Colonel Elijah Gates' brigade, captured a fortification known as Battery Powell, but were forced to retreat by Union reinforcements.