The 2022 San Diego Open was a combined men's and women's tennis tournament played on outdoor hard courts. It was the 2nd edition of the event for the men and the 1st edition of the Southern California Open for the women since 2015. The event is part of the ATP Tour 250 series of the 2022 ATP Tour and a WTA 500 event on the 2022 WTA Tour. It was held at the Barnes Tennis Center in San Diego, United States, from September 19 through September 25, 2022 for the men, and from October 10 through October 16, 2022 for the women.