The 2022 Malaysian motorcycle Grand Prix (officially known as the Petronas Grand Prix of Malaysia) was the nineteenth round of the 2022 Grand Prix motorcycle racing season. It was held at the Sepang International Circuit in Sepang on 23 October 2022. The Grand Prix returns to Malaysia after absences in 2020 and 2021 in response to the COVID-19 pandemic. In the MotoGP class, the Ducati Lenovo Team secured the Teams' Championship, their second consecutive and third overall.