The 2022 Chicago White Sox season was the club's 123rd season in Chicago, their 122nd in the American League and their 32nd at Guaranteed Rate Field. On December 2, 2021, Commissioner of Baseball Rob Manfred announced a lockout of players, following expiration of the collective bargaining agreement (CBA) between the league and the Major League Baseball Players Association (MLBPA). On March 10, 2022, the MLB and MLBPA agreed to a new collective bargaining agreement, thus ending the lockout. Opening Day was played on April 7. Although MLB previously announced that several series would be cancelled due to the lockout, the agreement provided for a 162-game season, with originally canceled games to be made up via doubleheaders.