The 2022 12 Hours of Sebring (formally known as the 70th Mobil 1 Twelve Hours of Sebring Presented by Advance Auto Parts) was an endurance sports car race held at Sebring International Raceway near Sebring, Florida from 16 to 19 March 2022. It was the second round of both the 2022 IMSA SportsCar Championship and the Michelin Endurance Cup. JDC-Mustang Sampling Racing entered as the defending overall winners of the 12-hour event.