The 2021 Virginia Tech Hokies football team represented Virginia Tech during the 2021 NCAA Division I FBS football season. The Hokies were led by sixth-year head coach Justin Fuente, prior to his departure following the Duke game. J. C. Price took over as the interim head coach for the final two games of the regular season and the bowl game. They played their home games at Lane Stadium in Blacksburg, Virginia, competing as members of the Atlantic Coast Conference (ACC). The Hokies accepted a bid to the Pinstripe Bowl to face Maryland, where they lost 54–10.