The 2021 USL League Two Playoffs was the post-season championship for the 2021 USL League Two season. It is the twenty-sixth edition of the Playoffs and the second under the USL League Two banner. The playoffs began on July 16 and ended with the USL League Two Final on July 31. There were no playoffs the previous season due to the COVID-19 pandemic. The Des Moines Menace won their third straight Regular Season Title (2018, 2019, 2021), with an average of 2.75 standings points per game. The Menace defeated North Carolina Fusion U23 in the National Final 1–0 before a record crowd of 7,342.