The 2021 Oklahoma Sooners softball team was an American college softball team that represented the University of Oklahoma during the 2021 NCAA Division I softball season. The Sooners were led by Patty Gasso in her twenty-seventh season, and played their home games at OU Softball Complex. They competed in the Big 12 Conference, where they finished the season with a 56–4 record, including 16–1 in conference play.