The 2021 Ohio Bobcats football team represented Ohio University in the 2021 NCAA Division I FBS football season. They were led by 1st-year head coach Tim Albin and played their home games at Peden Stadium in Athens, Ohio, as members of the East Division of the Mid-American Conference. The Bobcats finished the season 3–9 and 3–5 in the MAC to finish in third place in the East Division. This was Ohio's first losing season since 2008.