The 2021 Northern Illinois Huskies football team represented Northern Illinois University as a member of the West Division of the Mid-American Conference (MAC) during the 2021 NCAA Division I FBS football season. Led by third-year head coach Thomas Hammock, the Huskies compiled an overall record of 9–5 with a mark of 6–2 in conference playing, sharing the MAC's West Division title with Central Michigan. By virtue of a head-to-head win over Central Michigan, Northern Illinois advanced to the MAC Championship Game and defeated Kent State to win the program's six MAC championship. The Huskies ivited to the Cure Bowl, where they lost to Coastal Carolina on December 17. The team played home games at Huskie Stadium in DeKalb, Illinois.