The 2021 Newcastle Knights season was the 34th in the club's history. Coached by Adam O'Brien and co-captained by Jayden Brailey, Kalyn Ponga and Daniel Saifiti, they competed in the NRL's 2021 Telstra Premiership. In July, the NRL relocated the competition to Queensland to avoid an outbreak of the Deltra variant COVID-19 virus in New South Wales. The Knights finished the regular season in 7th place (out of 16), thus reaching the finals but were knocked out after losing to the Parramatta Eels in week 1.