The 2021 National Women's League, also known as Deputy Mayor National Women's League was the 2021 edition of the first-tier women's club football competition in Nepal organized by the All Nepal Football Association. The season started on 21 January. It was the first season since 2017/18, as the 2020 season was cancelled due to the COVID-19 pandemic in Nepal. APF Club was crowned champions on 17 February 2021.