The 2021 Houston Baptist Huskies football team represented Houston Baptist University—now known as Houston Christian University—as a member of the Southland Conference during the 2021 NCAA Division I FCS football season. Led by ninth-year head coach Vic Shealy the Huskies compiled an overall record of 0–11 with a mark of 0–8 in conference play, placing last out of six teams teams in the Southland. Houston Baptist played home games at Husky Stadium in Houston.