The 2021 Festival Luxembourgeois du cyclisme féminin Elsy Jacobs (known as the Ceratizit Festival Elsy Jacobs for sponsorship reasons) was a women's road cycling stage race that was held in Luxembourg from 30 April to 2 May 2021. It was the 13th edition of the Festival Elsy Jacobs and the first as a category 2.Pro event in the after its promotion after the 2019 season and the cancellation of the 2020 edition of the race.