The 2021 FC Cincinnati season was the club's third season in MLS, and the sixth season of a team playing under the FC Cincinnati brand after three years in the lower-division USL Championship. The club finished with a league worst 4–15–4 record in their second MLS season in 2020, one shortened by the COVID-19 pandemic in Ohio. The season was the first year that FC Cincinnati played home matches at newly built TQL Stadium.