The 2021 Emilia Romagna motorcycle Grand Prix (officially known as the Gran Premio Nolan del Made in Italy e dell'Emilia-Romagna) was the sixteenth round of the 2021 Grand Prix motorcycle racing season. It was held at the Misano World Circuit Marco Simoncelli in Misano Adriatico on 24 October 2021. In the MotoGP class, Fabio Quartararo became the first French rider to win the MotoGP World Championship after main rival Francesco Bagnaia crashed out of the lead with five laps to go therefore clinching the championship with two grand prix remaining in the season.