The 2021 Drive for the Cure 250 was a NASCAR Xfinity Series race that was held on October 9, 2021, at the Charlotte Motor Speedway in Concord, North Carolina. Contested over 68- extended from 67 laps due to an overtime finish—laps on the 2.28 mi (3.67 km) road course, it was be the 29th race of the 2021 NASCAR Xfinity Series season, the third race of the Playoffs, and the final race of the Round of 12.