The 2021 Conference USA Football Championship Game was a college football game played on December 3, 2021, at the Alamodome in San Antonio, Texas. It was the 17th edition of the Conference USA Football Championship Game and determined the champion of Conference USA (C–USA) for the 2021 season. The game began at 6:00 p.m. CST and aired on CBS Sports Network. The contest featured the hosts and West Division champion UTSA and the East Division champion Western Kentucky. Sponsored by tax services and consulting firm Ryan LLC, the game was officially known as the Ryan Conference USA Football Championship Game.