The 2021–22 UMass Lowell River Hawks men's basketball team represented the University of Massachusetts Lowell in the 2021–22 NCAA Division I men's basketball season. They played their home games at the Costello Athletic Center in Lowell, Massachusetts and were led by ninth-year head coach Pat Duquette. They finished the season 15-16, 7-11 in America East Play to finish in 7th place. They lost in the quarterfinals of the America East tournament to UMBC.