The 2021–22 UConn Huskies women's basketball team represented the University of Connecticut (UConn) during the 2021–22 NCAA Division I women's basketball season. The Huskies, led by Hall of Fame head coach Geno Auriemma in his 37th season at UConn, split their home games between Harry A. Gampel Pavilion and the XL Center and were members of the Big East Conference, which they joined for women's basketball the previous season. UConn was a member of the original Big East Conference from 1979 through 2013, and one of the original women's basketball teams in that conference in 1982.