The 2021–22 St. Bonaventure Bonnies men's basketball team represented St. Bonaventure University during the 2021–22 NCAA Division I men's basketball season. The Bonnies, led by 15th-year head coach Mark Schmidt, played their home games at the Reilly Center in Olean, New York as members of the Atlantic 10 Conference. They finished the season 23–10, 12–5 in A-10 play to finish in fourth place. They lost in the quarterfinals of the A-10 tournament to Saint Louis. They received an at-large bid to the National Invitation Tournament where they defeated Colorado, Oklahoma, and Virginia to advance to the semifinals. There they lost to Xavier.