The 2021–22 Premier 15s is the 5th season of the Premier 15s (23rd including editions of the previous Women's Premiership), of the top flight of English domestic women's rugby union competition and the second to be sponsored by Allianz. Incorporated in the season also was the inaugural Allianz Cup, a women's equivalent of the Premiership Rugby Cup. Saracens Women, who finished top of the league table during the regular season, won their third Premiers 15s title on 3 June 2022, after defeating Exeter Chiefs Women by 43–21 in the play-off final.