The 2021–22 Pac-12 Conference men's basketball season began with practices starting in October, followed by the 2021–22 NCAA Division I men's basketball season which started on November 9. Conference play began on November 28. This is the tenth season under the Pac–12 Conference name and the 62nd since the conference was established under its current charter as the Athletic Association of Western Universities in 1959. Including the history of the Pacific Coast Conference, which operated from 1915 to 1959 and is considered by the Pac-12 as a part of its own history, this is the Pac-12's 106th season of basketball.