The 2021–22 Ohio Bobcats women's basketball team represented Ohio University during the 2021–22 NCAA Division I women's basketball season. The Bobcats, led by ninth year head coach Bob Boldon, played their home games at the Convocation Center in Athens, Ohio as a member of the Mid-American Conference.The Bobcats finished non-conference play at 6–3. During a conference win at Central Michigan on January 15, Cece Hooks passed Caroline Mast as the leading scorer in Ohio basketball history. Two games later, against Bowling Green, she passed Toldeo’s Kim Knuth as the leading scorer in MAC basketball history. They finished the regular season 15–13 and 9–10 in the MAC. They were knocked out of the MAC tournament in the quarterfinals by top-seeded Toledo and in the first round of the WNIT by South